Thermo Fisher Scientific GUK1 Polyclonal Antibody
Thermo Fisher Scientific의 GUK1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot, IHC, ICC, ELISA에 적합합니다. Rabbit에서 유래한 Polyclonal 항체로, Protein A로 정제되었으며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human GUK1 (amino acids 10–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP, essential for recycling GMP and indirectly cGMP. It is a conserved monomeric protein (~200 amino acids) found in prokaryotes, lower eukaryotes, and vertebrates. GK shares structural similarity with Vaccinia virus protein A57R (SalG2R). Proteins containing DHR, SH3, and GK-like domains are termed MAGUKs (membrane-associated guanylate kinase homologs), including Drosophila dlg1, mammalian Zo-1, SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1, SAP102, erythrocyte p55, C. elegans lin-2, rat CASK, and human DLG2, DLG3. GK has an ATP-binding site (P-loop) in the N-terminal region, which is not conserved in GK-like domains of MAGUKs, though key binding residues remain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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