Thermo Fisher Scientific ITGA4/CD49D/Integrin alpha-4 Polyclonal Antibody
Rabbit polyclonal antibody against human Integrin alpha-4 (CD49d/ITGA4). Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL, unconjugated. Recommended storage at 4°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 982 to 1032 of human Integrin alpha-4 (CD49d, ITGA4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric membrane proteins composed of alpha and beta chains. The alpha4 chain associates with either beta1 or beta7 chains. Ligand-binding sites of integrin alpha4beta1 and alpha4beta7 are located on the alpha4 chain, binding ligands such as MadCAM, VCAM, and fibronectin. MadCAM is the principal ligand for integrin alpha4beta7. It has been shown that HIV-1 envelope can mimic MadCAM by binding to and signaling through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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