Thermo Fisher Scientific IRF7 Monoclonal Antibody (2A1)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:200

Product Specifications

Target Information

Interferons (IFNs) are involved in various immune interactions during viral infections and play a major role in the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions signal downstream molecules such as transcription factors including IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 is known to participate in transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
It plays a major role in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, though their functions are not clearly established.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.