Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI5D7)
NAB2 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(파라핀 절편) 실험에 적합. 인간 시료에 반응하며, 액상 형태로 제공. 고순도 친화 크로마토그래피 정제 및 안정한 보관 버퍼 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724787 |
Target Information
Transcriptional control is regulated in part by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins). The conserved NAB proteins, NAB1 and NAB2, act as corepressors of EGF-1/NGFI-A. Both contain an N-terminal NAB conserved domain 1 (NCD1), required for NGFI-A binding, and a C-terminal NCD2 domain responsible for repressor function. NAB2 is mainly localized in the nucleus and may play a role in downregulating NGFI-A activity, as well as in controlling cell division, differentiation, and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and is located on chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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