Thermo Fisher Scientific IARS2 Polyclonal Antibody
IARS2 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용 가능. Human, Mouse, Rat 반응성 보유. 고순도 Affinity Chromatography 정제 및 -20°C 보관.
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Thermo Fisher Scientific IARS2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IARS2 (Accession Q9NSE4), corresponding to amino acid residues G77–A127 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854204 |
Product Specific Information
Antibody detects endogenous levels of total IARS2.
Target Information
The Trip230 gene encodes a protein of 1,978 amino acids with an estimated molecular mass of 230 kDa. The gene is located on chromosome 14q31, which is in a region associated with genetic alterations and thyroid hormone response abnormalities. The Trip230 protein interacts with Rb and thyroid hormone receptor (TR) using two distinct domains. Complex formation with Rb is hormone-independent, while Trip230–TR complex formation is thyroid hormone-dependent. After T3 treatment, Trip230 is phosphorylated and transported to the nucleus, suggesting phosphorylation is important for nuclear translocation.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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