Thermo Fisher Scientific KCNN1 Polyclonal Antibody
KCNN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. Lyophilized 형태로 공급되며 -20°C에 보관. 신경세포의 칼슘 활성화 칼륨 채널 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:400 | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)DRPGSGKPPTVSHRLGHRR corresponding to amino acid residues 75–93 of rat KCa2.1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.6 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736013 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and influence neuronal firing patterns. Each AHP component is kinetically distinct and mediated by different calcium-activated potassium channels.
The KCNN1-encoded protein is activated before membrane hyperpolarization and regulates neuronal excitability by contributing to the slow component of synaptic AHP. It forms a voltage-independent calcium-activated channel with three calmodulin-binding subunits and belongs to the KCNN family of potassium channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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