Thermo Fisher Scientific TIM3 Polyclonal Antibody
Human TIM3 단백질을 인식하는 Goat Polyclonal Antibody로, WB, ICC/IF, Flow Cytometry에 적합. HAVCR2 내부 아미노산 서열을 면역원으로 사용. 액상 형태이며 0.5 mg/mL 농도, TBS 버퍼에 0.5% BSA 포함. 연구용 전용 시약.
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- PA518470
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Thermo Fisher Scientific TIM3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | 10 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KWYSHSKEKIQN) corresponding to internal amino acids of HAVCR2 (aa 225–237) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981436 |
Product Specific Information
- Predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
It is involved in macrophage activation and induction of autoimmune diseases, down-regulates aggressive Th1-mediated immune responses, and facilitates immune tolerance development.
Pathological significance has been linked to experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, enhancing its severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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