Thermo Fisher Scientific CNOT6 Polyclonal Antibody
CNOT6 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 버퍼에 보관되며 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CNOT6 (Accession Q9ULM6), corresponding to amino acid residues Y495–L545 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849954 |
Product Specific Information
Antibody detects endogenous levels of total CNOT6.
Target Information
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex, a major cellular mRNA deadenylase linked to processes such as mRNA degradation, miRNA-mediated repression, translational repression, and transcription regulation. Also involved in mRNA decay mediated by the mCRD of the FOS gene. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors including RARA, with limited effect on ESR1-mediated transcription. Mediates cell proliferation and survival, preventing cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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