Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI2D10), TrueMAB
COMMD1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로 Western blot, IHC, Flow cytometry에 사용 가능. 고순도 액상 형태로 제공되며 PBS/BSA/glycerol 버퍼에 저장. 세포 내 단백질 유비퀴틴화 조절 연구에 적합.
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Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI2D10), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D10 |
| Immunogen | Full length human recombinant protein of human COMMD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Proposed scaffold protein implicated in diverse physiological processes, partly linked to regulation of ubiquitination of specific cellular proteins. Modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promoting CRL E3 activity and dissociating CAND1 from CUL1 and CUL2. Promotes ubiquitination and proteasomal degradation of NF-kappa-B subunit RELA, leading to down-regulation of NF-kappa-B activity. Regulates membrane expression and ubiquitination of SLC12A2 and modulates Na(+) transport in epithelial cells through ENaC subunit regulation. Promotes localization of SCNN1D to recycling endosomes and enhances CFTR surface expression. Involved in copper ion homeostasis and copper-dependent ATP7A trafficking, functioning within the CCC complex and cooperating with the WASH complex. Binds one copper ion per monomer and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Also regulates HIF1A-mediated transcription by competing with ARNT/Hif-1-beta, resulting in decreased DNA binding and impaired transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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