Thermo Fisher Scientific RAB5A Monoclonal Antibody (5D1)
RAB5A 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(5D1)입니다. Western blot과 ELISA에 사용 가능하며, 인간 및 마우스 시료에 반응합니다. 비결합형 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5D1 |
| Immunogen | RAB5A (AAH01267, 116 a.a. ~215 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
KELQRQASPN IVIALSGNKA DLANKRAVDF QEAQSYADDN SLLFMETSAK TSMNVNEIFM AIAKKLPKNE PQNPGANSAR GRGVDLTEPT QPTRNQCCSN
Target Information
RAB5 belongs to the small GTPase Rab family, which are key regulators of intracellular membrane trafficking, from vesicle formation to membrane fusion. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form, recruiting downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
RAB5A is required for the fusion of plasma membranes and early endosomes, contributes to filopodia extension, and is essential for the exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also regulates the maturation of apoptotic cell-containing phagosomes, likely downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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