Thermo Fisher Scientific IL-2 Monoclonal Antibody (297C16F11)
인간 IL-2에 특이적인 마우스 단클론 항체로, IHC, 중화, 도트 블롯 등 다양한 면역학적 분석에 사용 가능. IL-2의 p55 수용체 결합을 억제하며, 고순도(>95%)와 높은 결합력(Kd 1.8×10⁻⁹)을 보유. 연구용으로만 사용.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
- Publications: View 1 publication
Neutralization (Neu)
- Tested Dilution: Assay-dependent
- Publications: View publication
Dot blot (DB)
- Tested Dilution: Assay-dependent
- Publications: View publication
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
- Publications: View publication
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 297C16F11 |
| Immunogen | Recombinant human IL-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536257 |
Product Specific Information
- Purity: >95% by SDS-PAGE
- Kd: 1.8 × 10⁻⁹
- This product can inhibit the binding of IL-2 on the p55 receptor.
Target Information
Interleukin 2 (IL-2) is an immuno-modulatory cytokine crucial for the proliferation of activated T cells and the differentiation of B cells, NK cells, monocytes, and macrophages.
IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric complex whose gamma chain is shared by IL-4 and IL-7.
Expression of the IL-2 gene in mature thymocytes is monoallelic, representing a unique regulatory mode for precise gene control.
Disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease, indicating its essential role in immune response to antigenic stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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