Thermo Fisher Scientific IL-2 Monoclonal Antibody (297C16F11)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent
• Publications: View 1 publication

Neutralization (Neu)

• Tested Dilution: Assay-dependent
• Publications: View publication

Dot blot (DB)

• Tested Dilution: Assay-dependent
• Publications: View publication

Inhibition Assays (IA)

• Tested Dilution: Assay-dependent
• Publications: View publication

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• Purity: >95% by SDS-PAGE
• Kd: 1.8 × 10⁻⁹
• This product can inhibit the binding of IL-2 on the p55 receptor.

Target Information

Interleukin 2 (IL-2) is an immuno-modulatory cytokine crucial for the proliferation of activated T cells and the differentiation of B cells, NK cells, monocytes, and macrophages.
IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric complex whose gamma chain is shared by IL-4 and IL-7.
Expression of the IL-2 gene in mature thymocytes is monoallelic, representing a unique regulatory mode for precise gene control.
Disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease, indicating its essential role in immune response to antigenic stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.