Thermo Fisher Scientific CRYBA1 Polyclonal Antibody
Human CRYBA1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:500~1:1,000 희석 비율로 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA582785
- 판매단위
- pk
카탈로그
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRYBA1. Recombinant protein control fragment (Product #RP-108316). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789941 |
Product Specific Information
Immunogen sequence:METQAEQQEL ETLPTTKMAQ TNPTPGSLGP WKITIYDQEN FQGKRMEFTS SCPNVSERSF DNVRSLKVES
Target Information
Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class constitutes the major proteins of vertebrate eye lens, maintaining transparency and refractive index. Lens central fiber cells lose nuclei during development, so crystallins are retained throughout life, making them extremely stable.
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins form a superfamily. Alpha and beta families are further divided into acidic and basic groups. Beta-crystallins differ by the presence of a C-terminal extension (present in basic group, absent in acidic group). Beta-crystallins form aggregates and can self-associate or form heterodimers with other beta-crystallins.
This gene, a beta acidic group member, encodes two proteins (crystallin beta A3 and beta A1) from a single mRNA. The beta A1 protein is 17 amino acids shorter than beta A3, generated by an alternate translation initiation site. Deletion of exons 3 and 4 causes autosomal dominant “zonular cataract with sutural opacities”.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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