Thermo Fisher Scientific Doublecortin Polyclonal Antibody
Doublecortin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 인간에 반응하며, 마우스·랫·치킨·소에서도 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 154–441 of Human Doublecortin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546012 |
Product Specific Information
- Recommended positive controls: Raji, human DCX-transfected 293T
- Predicted reactivity: Mouse (99%), Rat (97%), Chicken (94%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein that directs neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains that bind microtubules. This protein also interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, which is important for proper microtubule function in the developing cortex. Mutations in the DCX gene cause X-linked lissencephaly.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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