Thermo Fisher Scientific CCM2 Monoclonal Antibody (OTI2F9), TrueMAB
Human CCM2 단백질을 인식하는 mouse monoclonal antibody로 Western blot, IHC, ICC/IF에 사용 가능. TrueMAB 포맷으로 높은 특이성과 재현성을 제공. 액상 형태, 0.65 mg/mL 농도, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F9 |
| Immunogen | Full length human recombinant protein of human CCM2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. It is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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