Thermo Fisher Scientific PTPLAD1 Monoclonal Antibody (5B5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MENQVLTPHV YWAQRHRELY LRVELSDVQN PAISITENVL HFKAQGHGAK GDNVYEFHLE FLDLVKPEPV YKLTQRQVNI TVQKKVSQWW ERLTKQEKRP LFLAPDFDRW LDE

Target Information

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of two carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor (INSR) autophosphorylation and is involved in INSR internalization (PubMed:25687571).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.