Thermo Fisher Scientific EXOSC7 Monoclonal Antibody (OTI1G8), TrueMAB

Thermo Fisher Scientific EXOSC7 Monoclonal Antibody (OTI1G8), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

EXOSC7 is a non-catalytic component of the RNA exosome complex, which exhibits 3'→5' exoribonuclease activity and is involved in various RNA processing and degradation events.
In the nucleus, it contributes to maturation of rRNA, snRNA, snoRNA, and elimination of RNA processing by-products and non-coding transcripts (e.g., antisense RNA, PROMPTs). It also plays a role in preventing export of defective mRNAs to the cytoplasm.
EXOSC7 may participate in immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) by guiding AICDA deamination activity.
In the cytoplasm, it is involved in mRNA turnover, degradation of AU-rich element-containing mRNAs, and RNA surveillance to prevent translation of aberrant transcripts.
The Exo-9 core complex serves as a scaffold for catalytic subunits and accessory proteins, facilitating RNA binding and degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(본 상품의 관련 이미지가 여기에 표시됩니다)