Thermo Fisher Scientific TNFRSF13B Monoclonal Antibody (1G1)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Protein sequence:

SGLGRSRRGG RSRVDQEERF PQGLWTGVAM RSCPEEQYWD PLLGTCMSCK TICNHQSQRT CAAFCRSLSC RKEQGKFYDH LLRDCISCAS ICGQHPKQCA YFCENKLRSP VNLPPELRRQ RSGEVENNSD NSGRYQGLEH RGSEASPALP GLKLSADQVA LVYS

Target Information

Members of the TNF superfamily regulate immune responses and induce apoptosis. Two novel members, BAFF (also known as BLyS, TALL-1, THANK, zTNF4) and April (TALL-2), have been identified.
BAFF acts as a B cell activator, inducing B cell proliferation and immunoglobulin secretion, while April regulates both immunological and non-immunological cell growth.
Three receptors—BCMA, TACI, and BAFF-R—interact with BAFF and April. TACI, like BCMA, binds both ligands and plays a role in regulating humoral immune responses, activating NF-kappa-B and c-Jun N-terminal kinase, and contributing to B cell–associated autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.