Thermo Fisher Scientific FRMPD1 Polyclonal Antibody, MaxPab

Thermo Fisher Scientific FRMPD1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The sequence of this protein is as follows:
MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT LIPVRHTVKI DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI LQMNNEPAED LSWERAVDIL REAEDSLSIT VVRCTSGVPK SSFLTEEKRA RLKTNPVKVH FAEEVLISGH SQGNSLLCMP NVLKLYLENG QTKAFKFEAN TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE EELIQQVVER EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK GKDIKKAISF HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI FNATLMLQDR ESYIALLVGA KYGISQVINS KLNIMSTLAE FANISRVELT EESEKVSVVK VYLQDVKVLT LLLESNSAKD LACLIAGYYR LLVDPVTSIF LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS DRRLVKLAPC RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI ETSGFLCLLD LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE GSHADYYSLC SSVSPASYLS DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM LEPLALHPPL AFEDGSSDEE YYDAADKLTP PGPPSGPRDV STAEPSATSL QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS FLQTDYTSQV SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP NNKENSGVVP AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA PKEPTIEHGD SSFSLSSGDP NPDRACLASN PGLNNVSQGD TLELQLEPHV QLEMGLESFC TNHIQETAPK YTEPLLSPRD EPRSDECGIN PGEKIASIPT KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV SNNVSQTLDI SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF NPEPSLPEPL PCPQEDPHLE TSNHCLLLEG KSDSSSICLS AEKSFLCFAP ESHPEVSASL RVATSLGFAG MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW RPARAHSCTT APLSRKSHIW PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW GVGNKHPPEK CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS VKLLARQCTA LTAAVFCLTQ KFRASTAL

Target Information

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, ezrin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occludens-1) domain.
FRMPD1 was initially identified through yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that stabilizes the GDP-bound conformation of Gαi. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in neuronal cells decreased endogenous AGS3 levels in membrane fractions by ~50% and enhanced inhibition of forskolin-induced cAMP increases.
Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with AGS3–Gαi3 interaction, suggesting FRMPD1 may position AGS3 in the membrane for Gαi interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: H00022844-B01P_FRMPD1_Q5SYB0-1_House_mouse.svg)
(이미지 파일명: H00022844-B01P_FRMPD1_Q5SYB0-1_House_mouse_PDP.jpeg)