Thermo Fisher Scientific Clostridium botulinum Toxin B VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA0977)

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Bacteria

Host/Isotype

Alpaca / VHH

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SAA0977

Immunogen

Recombinant Clostridium botulinum BoNT/B.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Metal-chelate chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Product Specific Information

Compatible with Direct ELISA

Target Information

Clostridium botulinum Toxin B (BoNT/B) is one of the protein neurotoxins produced by the bacteria Clostridium botulinum, which is a Gram-positive, anaerobic organism. BoNT/B, along with other botulinum toxins, is a primary virulence factor responsible for causing botulism, a serious and potentially fatal condition characterized by flaccid paralysis. BoNT/B specifically targets peripheral nerve terminals, inhibiting the release of neurotransmitters by cleaving synaptic vesicle-associated proteins, thus preventing synaptic vesicle fusion with the nerve terminal membrane. This blockade at neuromuscular junctions leads to prolonged muscle paralysis. Structurally, BoNT/B, like other botulinum toxins, consists of a heavy chain and a light chain connected by a disulfide bond. The heavy chain facilitates binding to neuronal cells and translocation into the cytosol, while the light chain acts as a protease to cleave specific proteins involved in neurotransmitter release.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.