Thermo Fisher Scientific MAD4 Polyclonal Antibody
Rabbit polyclonal antibody against recombinant human MAD4. Unconjugated liquid form with 0.1 mg/mL concentration. Suitable for research use in studying transcriptional regulation and tumor suppression. Store at 4°C short term or -20°C long term.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MAD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663301 |
Product Specific Information
Immunogen sequence:
HGYASVLPFDG DFAREKTKAA GLVRKAPNNR SSHNEL
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
This gene belongs to the MAD gene family. The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein to form a transcriptional repression complex.
MAD proteins compete with MYC for MAX binding; MYC-MAX complexes act as transcriptional activators, while MAD-MAX complexes act as repressors.
Rodent studies suggest that MAD genes function as tumor suppressors and play roles in regulating cell growth in differentiating tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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