Thermo Fisher Scientific RelB Recombinant Rabbit Monoclonal Antibody (HL2222)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

The NFkB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNA-binding subunit is functionally related to c-Rel p75 and RelB p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NFkB subunit. RelB does not bind with high affinity to NFkB sites, but heterodimers between RelB and p50 bind with an affinity comparable to that of p50 NFkB homodimers. However, RelB/p50 heterodimers, in contrast to NFkB heterodimers, transactivate transcription of promoters containing kB binding sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.