Thermo Fisher Scientific BUB1B Monoclonal Antibody (OTI3C7), TrueMAB

Applications

• ELISA (ELISA)
  Tested Dilution: 1:100–1:1,000

Product Specifications

Target Information

BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint and monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers and identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which may accelerate the progression of breast cancer by compromising mitotic checkpoint control through inactivation of BUBR1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.