Thermo Fisher Scientific BUB1B Monoclonal Antibody (OTI3C7), TrueMAB
인간 BUB1B 단백질을 인식하는 단클론 항체로, ELISA 등 면역분석에 적합합니다. HEK293T 세포에서 발현된 재조합 단백질을 면역원으로 사용했습니다. 고순도의 액상 형태이며, PBS 버퍼와 트레할로스, 아지드가 포함되어 안정성이 우수합니다. 연구용으로만 사용 가능합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C7 |
| Immunogen | Full length human recombinant protein of human BUB1B produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint and monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers and identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which may accelerate the progression of breast cancer by compromising mitotic checkpoint control through inactivation of BUBR1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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