Thermo Fisher Scientific DNMT3L Polyclonal Antibody
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DNMT3L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 검증 완료. 인간 및 비인간 영장류 반응성. 단백질 A로 정제된 액상 항체로 연구용 DNA 메틸화 관련 단백질 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 2–4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Amino acids 25–75 of human DNMT3L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718864 |
Target Information
Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification essential for gene expression regulation, genomic imprinting, and development. Mammalian DNA methyltransferases include DNMT1, DNMT2, and DNMT3 families.
- DNMT1: Maintenance methyltransferase, active in proliferating cells.
- DNMT3A / DNMT3B: De novo methyltransferases, highly expressed in embryonic stem cells.
- DNMT2: Low expression, minimal role in methylation maintenance.
- DNMT3L: Catalytically inactive regulator of DNMT3A/B, expressed in embryonic stem cells, testis, ovaries, and thymus. Forms heterotetrameric complexes with DNMT3A/B. Contains an amino-terminal ADD domain and a carboxy-terminal methyltransferase-like domain.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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