Thermo Fisher Scientific IRF3 Monoclonal Antibody (OTI5D2), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

IRF3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses.
It plays a critical role in the innate immune response against DNA and RNA viruses by regulating transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG).
Inactive in the cytoplasm of uninfected cells, IRF3 becomes phosphorylated by IKBKE and TBK1 upon viral infection, leading to dimerization, nuclear localization, and activation of IFN gene transcription.
Mutations in IRF3 can cause acute, infection-induced herpes-specific encephalopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.