Thermo Fisher Scientific Phospho-AKT1 (Ser473) Monoclonal Antibody (104A282)
Phospho-AKT1 (Ser473)을 검출하는 Mouse Monoclonal Antibody로 Western blot, IHC, ICC 등 다양한 응용 가능. Human, Mouse 등 다종 반응성. Protein G 정제, PBS buffer, 1 mg/mL 농도. 세포 생존 및 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:250 | – |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | – |
| ChIP assay (ChIP) | Assay-Dependent | – |
| Luminex (LUM) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Zebrafish |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 104A282 |
| Immunogen | Synthetic peptide containing phosphorylated serine at residue 473 of human Akt1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557538 |
Product Specific Information
MA1-20325 detects phospho-AKT1 (pS473) in human and mouse samples.
Target Information
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1, and other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors and caspase-9. The AKT pathway is a major target for cancer drug discovery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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