Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Arg3.1(ARC) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드 면역원 사용. 단백질 시냅스 가소성 및 장기 기억 연구에 적합. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat Arg3.1 (ARC) conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and human.
- Specificity: Arg3.1/ARC.
Target Information
Arg3.1 (ARC) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs, mediating intercellular RNA transfer in the nervous system.
ARC protein is released from neurons via extracellular vesicles that transfer ARC mRNA into target cells, enabling activity-dependent translation.
It regulates synaptic plasticity by promoting AMPA receptor endocytosis, maintaining surface AMPAR levels, and contributing to neuronal homeostasis.
ARC acts as a mediator of activity-dependent synapse elimination, required for long-term potentiation (LTP), long-term depression (LTD), and memory formation.
Additionally, ARC is involved in immune regulation, expressed in skin-migratory dendritic cells, and influences T-cell activation through dendritic cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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