Thermo Fisher Scientific 4-1BB Ligand Polyclonal Antibody
Human 4-1BB Ligand(CD137L)을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. A549, HeLa 등 다양한 세포주에서 검증되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 49–254 of Human TNFSF9 (4-1BBL, CD137L, UniProt ID: P41273-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548398 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells such as dendritic cells, monocytes/macrophages, and B cells, and is upregulated upon activation.
Its receptor, CD137 (4-1BB), is expressed on various cells including activated T cells and inflamed endothelial cells. Interaction between CD137 and CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is also expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma) but is absent in Hodgkin and T-cell lymphomas. Additionally, it is found in carcinoma cell lines and may play a role in T cell–tumor cell interactions.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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