Thermo Fisher Scientific Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (extracellular) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL double distilled water (DDW) depending on sample size.
• Ships as lyophilized powder at room temperature.
• Store at -20°C upon arrival.
• Reconstituted solution can be stored at 4°C for up to 1 week; for longer periods, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

CHRNA4 encodes a nicotinic acetylcholine receptor subunit belonging to the ligand-gated ion channel superfamily, mediating fast synaptic transmission. These pentameric receptors bind acetylcholine, inducing conformational changes that open ion channels across the plasma membrane. The alpha 4 subunit interacts with nAChR beta-2 or beta-4 to form functional receptors. Mutations in CHRNA4 are linked to nocturnal frontal lobe epilepsy type 1, and certain polymorphisms confer protection against nicotine addiction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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