Thermo Fisher Scientific Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (extracellular) Polyclonal Antibody
CHRNA4 단백질의 세포외 영역을 인식하는 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. WB, IHC(F), Flow Cytometry에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공. 연구용으로만 사용.
- 카탈로그번호
- ANC-004-xxxxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (extracellular) Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:300 |
| Flow Cytometry (Flow) | 2.5 µg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)DLVNMHSRVDQLD, corresponding to amino acid residues 190–202 of human nAChR alpha 4, extracellular N-terminus |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitution: Add 25 µL, 50 µL, or 0.2 mL double distilled water (DDW) depending on sample size.
- Ships as lyophilized powder at room temperature.
- Store at -20°C upon arrival.
- Reconstituted solution can be stored at 4°C for up to 1 week; for longer periods, aliquot and store at -20°C.
- Avoid multiple freeze/thaw cycles.
- Centrifuge all antibody preparations before use (10,000 × g, 5 min).
Target Information
CHRNA4 encodes a nicotinic acetylcholine receptor subunit belonging to the ligand-gated ion channel superfamily, mediating fast synaptic transmission. These pentameric receptors bind acetylcholine, inducing conformational changes that open ion channels across the plasma membrane. The alpha 4 subunit interacts with nAChR beta-2 or beta-4 to form functional receptors. Mutations in CHRNA4 are linked to nocturnal frontal lobe epilepsy type 1, and certain polymorphisms confer protection against nicotine addiction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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