Thermo Fisher Scientific CD3e Monoclonal Antibody (BB23-8E6), FITC

Applications

• Flow Cytometry (Flow): Tested at 3 µg/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA5-28774)
• Biotin (MA5-28771)
• PE (MA5-28773)
• Custom conjugation available upon request

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor involves the cytoplasmic tails of the CD3 subunits (CD3 gamma, delta, epsilon, and zeta). These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components associate with cytoplasmic signal transduction molecules through a double tyrosine-based motif. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on most T lymphocytes and thymocytes but not on B or NK cells. Decreased T lymphocyte percentages may occur in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지