Thermo Fisher Scientific CD3e Monoclonal Antibody (BB23-8E6), FITC
돼지 CD3e 인식 단일클론 항체로, FITC 형광표지되어 유세포분석(Flow Cytometry)에 적합합니다. 마우스 IgG2b 아이소타입이며 0.5 mg/mL 농도의 액상 형태로 제공됩니다. PBS(pH 7.4) 용액에 0.1% 미만의 sodium azide를 포함하며, 4°C 암소 보관이 권장됩니다.
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Applications
- Flow Cytometry (Flow): Tested at 3 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BB23-8E6 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745731 |
Additional Formats
- Unconjugated (MA5-28774)
- Biotin (MA5-28771)
- PE (MA5-28773)
- Custom conjugation available upon request
Target Information
The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor involves the cytoplasmic tails of the CD3 subunits (CD3 gamma, delta, epsilon, and zeta). These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components associate with cytoplasmic signal transduction molecules through a double tyrosine-based motif. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on most T lymphocytes and thymocytes but not on B or NK cells. Decreased T lymphocyte percentages may occur in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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