Thermo Fisher Scientific Sortilin Polyclonal Antibody
Rabbit polyclonal antibody targeting Sortilin for WB and IHC applications. Synthetic peptide immunogen from rat Sortilin. Lyophilized form, reconstitutable in sterile water. Suitable for research use only, not for diagnostic procedures.
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Thermo Fisher Scientific Sortilin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat Sortilin conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1960716 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute in 500 µL of sterile water.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to the lysosomes by a pathway independent of the mannose-6-phosphate receptor (M6PR).
Sortilin also mediates protein transport from the Golgi apparatus to the endosomes and promotes neuronal apoptosis by endocytosis of proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB).
Additionally, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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