Thermo Fisher Scientific DRAK2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DRAK2 (STK17B) for ICC/IF applications. Recognizes recombinant PrEST antigen sequence (aa 2–42). Affinity purified, supplied in PBS with 40% glycerol. Suitable for apoptosis and T-cell signaling studies.
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Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 2–42). Recombinant protein control fragment (Product #RP-109796) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3092097 |
Product Specific Information
- Immunogen sequence: SRRRFDCRSI SGLLTTTPQI PIKMENFNNF YILTSKELGR G
- Antigen sequence identity: Mouse 88%; Rat 88%
Target Information
STK17B (also known as DRAK2) is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis. STK17B is selectively important for T-cell survival, and inhibition of STK17B has therapeutic potential for autoimmune diseases.
T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals, and deficiency of STK17B can affect autoimmune disease susceptibility without generalized suppression of the immune system.
Protein kinases play important roles in signal transduction in response to various external stimuli. Several kinases, including ZIP kinase, DRAK1, and DRAK2, have been implicated in apoptotic processes. Overexpression of these kinases in NIH 3T3 cells can induce morphological changes typical of apoptosis.
The C-terminal domain of DRAKs is important for apoptosis induction, suggesting a role in cell death signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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