Thermo Fisher Scientific DRAK2 Polyclonal Antibody

Applications and Tested Dilution

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: SRRRFDCRSI SGLLTTTPQI PIKMENFNNF YILTSKELGR G
• Antigen sequence identity: Mouse 88%; Rat 88%

Target Information

STK17B (also known as DRAK2) is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis. STK17B is selectively important for T-cell survival, and inhibition of STK17B has therapeutic potential for autoimmune diseases.
T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals, and deficiency of STK17B can affect autoimmune disease susceptibility without generalized suppression of the immune system.

Protein kinases play important roles in signal transduction in response to various external stimuli. Several kinases, including ZIP kinase, DRAK1, and DRAK2, have been implicated in apoptotic processes. Overexpression of these kinases in NIH 3T3 cells can induce morphological changes typical of apoptosis.
The C-terminal domain of DRAKs is important for apoptosis induction, suggesting a role in cell death signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.