Thermo Fisher Scientific IWS1 Polyclonal Antibody
IWS1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. 고순도 Affinity chromatography 정제, 액상 형태로 제공. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IWS1 (Accession Q96ST2), corresponding to amino acid residues M1–Q36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850091 |
Product Specific Information
Antibody detects endogenous levels of total IWS1.
Target Information
Transcription factor that plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A).
The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) and histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export, and elongation-coupled H3K36 methylation — a signature chromatin mark of active transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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