Thermo Fisher Scientific SCN4B Polyclonal Antibody
SCN4B 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에서 반응합니다. Western blot 및 ELISA에 적합하며 고순도 Affinity Chromatography로 정제되었습니다. 전기적 채널 조절 연구용으로 적합하며 -20°C에서 보관합니다.
- 카탈로그번호
- PA5110345
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 80–228 of mouse SCN4B (Q7M729) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855756 |
Product Specific Information
Immunogen sequence:
IDGIVKNDKS DPKVRVKDDD RITLEGSTKE KTNNISILLS DLEFSDTGRY TCFVRNPKEK DLNNSATIFL QVVDKLEKVD NTVTLIILAV VGGVIGLLVC ILLLKKLITF ILKKTREKKK ECLVSSSGND NTENGLPGSK AEEKPPTKV
Target Information
The SCN4B protein modulates channel gating kinetics. It causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.
SCN4B is expressed at high levels in dorsal root ganglia, and at lower levels in brain, spinal cord, skeletal muscle, and heart.
Defects in SCN4B are associated with long QT syndrome type 10 (LQT10) [MIM:611819], a cardiac disorder characterized by prolonged QT intervals and polymorphic ventricular arrhythmias, potentially leading to syncope or sudden death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-110345_SCN4B_Q7M729-1_Rabbit.svg, PA5-110345_SCN4B_Q7M729-1_Rabbit_PDP.jpeg)
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