Thermo Fisher Scientific HIP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_0053293) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HIP1,uniProtId:O00291-1,ncbiNodeId:9606,antigenRange:410-690,antigenLength:1037,antigenImageFileName:PA5-93288_HIP1_O00291-1_Rabbit.svg,antigenImageFileNamePDP:PA5-93288_HIP1_O00291-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806705

Product Specific Information

Immunogen sequence: SELEADLAEQ QHLRQQAADD CEFLRAELDE LRRQREDTEK AQRSLSEIER KAQANEQRYS KLKEKYSELV QNHADLLRKN AEVTKQVSMA RQAQVDLERE KKELEDSLER ISDQGQRKTQ EQLEVLESLK QELATSQREL QVLQGSLETS AQSEANWAAE FAELEKERDS LVSGAAHREE ELSALRKELQ DTQLKLASTE ESMCQLAKDQ RKMLLVGSRK AAEQVIQDAL NQLEEPPLIS CAGSADHLLS TVTSISSCIE QLEKSWSQYL ACPEDISGLL H; Positive Samples: A-549, BT-474, SW480, 293T, Mouse brain; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Endomembrane system, Nucleus, clathrin-coated vesicle membrane

Target Information

Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.