Thermo Fisher Scientific GITR/Tnfrsf18 Monoclonal Antibody (DTA-1)
마우스 GITR/TNFRSF18 단백질을 인식하는 DTA-1 클론의 단일클론 항체. ICC/IF 및 유세포분석에 적합하며, Rat IgG2b 아이소타입. Protein A/G로 정제된 액상형 항체로 4°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DTA-1 |
| Immunogen | Mouse CD25⁺ CD4⁺ T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans, mapped to chromosome 1p36.33. This receptor, part of the TNF-receptor superfamily, shows increased expression upon T-cell activation and plays a key role in maintaining immunological self-tolerance mediated by CD25⁺CD4⁺ regulatory T cells. Knockout studies in mice suggest its involvement in regulating CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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