Thermo Fisher Scientific CTDSP1 Monoclonal Antibody (OTI1G1)
CTDSP1 단백질을 타겟으로 하는 Thermo Fisher Scientific의 마우스 단클론 항체입니다. Western blot 및 IHC(P) 응용에 적합하며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 제공되며, 안정적인 저장 버퍼와 방부제가 포함되어 있습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Full length human recombinant protein of CTDSP1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724179 |
Target Information
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter gene constructs, while expression of a mutant lacking phosphatase activity enhances transcription. Neuronal gene transcription is repressed in nonneuronal cells by the REST/NRSF complex, which recruits SCPs to neuronal genes containing RE1 elements, leading to silencing. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells, indicating SCP activity is an evolutionarily conserved transcriptional regulator that silences neuronal genes globally.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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