Thermo Fisher Scientific Haptoglobin (HP) Monoclonal Antibody (HP/3839)

Thermo Fisher Scientific Haptoglobin (HP) Monoclonal Antibody (HP/3839)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: Human liver
• Cellular Localization: Secreted
• Selective granular cytoplasmic expression in liver with distinct positivity in plasma and extracellular matrix.

Specificity Comments:
Haptoglobin (Hp) is a blood plasma protein that binds free hemoglobin released from erythrocytes, inhibiting its oxidative activity. This binding also sequesters iron, preventing iron-utilizing bacteria from benefiting from hemolysis. Haptoglobin levels may increase during inflammation, and the Hp–Hb complex is cleared by the reticuloendothelial system.
Haptoglobin consists of two α and two β chains linked by disulfide bridges. In humans, two allelic forms exist (Hp1 and Hp2), producing three phenotypes: Hp1-1, Hp2-1, and Hp2-2. These may correlate with diabetes, cardiovascular disease, Parkinson’s, and Crohn’s disease.
Haptoglobin levels are useful for diagnosing hemolytic anemia and are expressed in hepatocytes as well as skin, lung, and kidney.

Target Information

Haptoglobin is an α2-globulin plasma protein synthesized in the liver. It acts as an acute phase protein and scavenger of hemoglobin from hemolyzed red cells. The monomer consists of two α and two β chains; α chains may be hp1Fa, hp1Sa, or hp2a types, while the β chain is constant.
Three major phenotypes are recognized: Hp1-1, Hp2-1, and Hp2-2, with hp1a chains existing in F or S types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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