Thermo Fisher Scientific USP25 Monoclonal Antibody (1277CT376.106.171)

Applications

• Western Blot (WB): Tested dilution 1:1,000

Product Specifications

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination, catalyzed by deubiquitinating enzymes (DUBs), provides an additional level of ubiquitin regulation and includes four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread family across evolution. They release ubiquitin from conjugated proteins and share conserved catalytic domains (Cys and His boxes) with variable terminal extensions that contribute to substrate recognition, localization, and protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.