Thermo Fisher Scientific PCDH18 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PCDH18. Recombinant protein control fragment (Product #RP-90578). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PCDH18,uniProtId:Q9HCL0-1,ncbiNodeId:9606,antigenRange:754-859,antigenLength:1135,antigenImageFileName:PA5-53686_PCDH18_Q9HCL0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53686_PCDH18_Q9HCL0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645252

Product Specific Information

Immunogen sequence: IHKGDITLVP TINGTLPIRS HHRSSPSSSP TLERGQMGSR QSHNSHQSLN SLVTISSNHV PENFSLELTH ATPAVEQVSQ LLSMLHQGQY QPRPSFRGNK YSRSYR

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.

Target Information

Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.