Thermo Fisher Scientific PCDH18 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 PCDH18 폴리클로날 항체. Western blot 및 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제된 비결합 항체. 장기 보관 시 -20°C에서 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- PA553686
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PCDH18. Recombinant protein control fragment (Product #RP-90578) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645252 |
Product Specific Information
Immunogen sequence:
IHKGDITLVP TINGTLPIRS HHRSSPSSSP TLERGQMGSR QSHNSHQSLN SLVTISSNHV PENFSLELTH ATPAVEQVSQ LLSMLHQGQY QPRPSFRGNK YSRSYR
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 99%
Target Information
Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules.
Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs.
Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea.
PCDH18 expression is temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development.
PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, suggesting a role during brain development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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