Thermo Fisher Scientific KIR2DL5B Polyclonal Antibody
KIR2DL5B 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. Western blot과 Immunoprecipitation에 사용 가능하며, 고순도 Affinity chromatography로 정제되었습니다. 연구용으로 안정적인 보관 및 재현성 높은 결과를 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunoprecipitation (IP) | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of human KIR2DL5B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689505 |
Product Specific Information
This target displays homology in the following species:
- Human: 100%
- Pig: 91%
Target Information
KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer (NK) cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
KIR proteins are classified by:
- The number of extracellular immunoglobulin domains (2D or 3D)
- The length of the cytoplasmic domain (long [L] or short [S])
Proteins with long cytoplasmic domains contain immune tyrosine-based inhibitory motifs (ITIM) and mediate inhibitory signals upon ligand binding. Those with short domains lack ITIM motifs and instead associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
KIR proteins play a crucial role in regulating immune responses. Functionally, KIR2DL5A and KIR2DL5B act as receptors on NK cells for HLA-C alleles, preventing cell lysis by inhibiting NK cell activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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