Thermo Fisher Scientific CIS Polyclonal Antibody
Western blot, IHC, ICC/IF에 적합한 Rabbit Polyclonal Antibody. Human과 Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 4°C 단기 보관, -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 196–258 of Human CIS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544604 |
Product Specific Information
- Recommended positive controls: HeLa, PC-12, Rat2
- Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CIS contains SH2 and SOCS box domains, classifying it within the cytokine-induced STAT inhibitor (CIS) family, also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI). These proteins act as cytokine-inducible negative regulators of cytokine signaling. Expression is induced by IL2, IL3, GM-CSF, and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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