Thermo Fisher Scientific CD34 Monoclonal Antibody (581), PE-Cyanine5.5
인간 CD34 단백질을 인식하는 마우스 단클론 항체로, PE-Cyanine5.5로 결합되어 있습니다. 유세포분석 및 면역조직화학에 적합하며, 줄기세포 표지 연구에 활용됩니다. 564/692 nm 형광 특성을 가지며, 4°C에서 보관합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- Publications: View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: 5 µL for 1×10⁶ cells
- Publications: View 9 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 581 |
| Immunogen | Human CD34 |
| Conjugate | PE-Cyanine5.5 |
| Excitation / Emission Max | 564 / 692 nm |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS with BSA, sucrose |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536504 |
Additional Formats
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on many stem cell populations. It serves as a stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 may function as a surface receptor involved in receptor-mediated endocytosis and regulation of adhesion, differentiation, and proliferation of hematopoietic stem cells and progenitors.
CD34 likely represents a specific developmental stage of hematopoietic cells with distinct adhesion properties. It may act as an adhesion molecule mediating stem cell attachment to the bone marrow extracellular matrix or stromal cells, and as a scaffold for lineage-specific glycans that enable binding to lectins on stromal or marrow components. Additionally, CD34 may present carbohydrate ligands to selectins. The intracellular domain can be phosphorylated by protein kinase C, suggesting a role in signal transduction.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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