Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI5C5), TrueMAB
인간 N4BP2L2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, IHC(P)에서 1:150 희석으로 사용 가능. TrueMAB 포맷의 고순도 항체이며, PBS/BSA/glycerol buffer에 보관. DNA 손상 반응 및 골수 발현 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C5 |
| Immunogen | Full length human recombinant protein of N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
It is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR.
Primarily expressed in bone marrow, N4BP2L2 is down-regulated after exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, both associated with neutropenia disorders.
Defects in ELA2, encoding Neutrophil Elastase, cause cyclic haematopoiesis, reducing neutrophil counts and increasing infection risk.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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