Thermo Fisher Scientific AMOT Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human AMOT. Recombinant protein control fragment (Product #RP-103986). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AMOT,uniProtId:Q4VCS5-1,ncbiNodeId:9606,antigenRange:174-237,antigenLength:1084,antigenImageFileName:PA5-64322_AMOT_Q4VCS5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64322_AMOT_Q4VCS5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637914

Product Specific Information

Immunogen sequence: LSERLMQMSL ATSGVKAHPP VTSAPLSPPQ PNDLYKNPTS SSEFYKAQGP LPNQHSLKGM EHRG

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Target Information

AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.