Thermo Fisher Scientific ZNF638 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ZNF638 for WB and IHC applications. Recognizes internal peptide region of ZNF638. Supplied as unconjugated liquid form, 1 mg/mL concentration. Suitable for transcriptional regulation studies and DNA-binding pr...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human ZNF638 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555276 |
Target Information
Zinc-finger proteins contain DNA-binding domains and have diverse functions, primarily involving transcriptional activation or repression. NP220 (Nuclear protein 220), also known as Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein with one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation.
NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines and interacts with FHL-2. It is thought to be phosphorylated by ATM or ATR upon DNA damage. NP220 exists as five isoforms due to alternative splicing. Isoform five acts as a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL) cases, including mycosis fungoides and Sezary syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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