
Thermo Fisher Scientific ZP2 Polyclonal Antibody
Thermo Fisher Scientific ZP2 Polyclonal Antibody는 인간 및 비인간 영장류 시료에서 ZP2 단백질을 검출하는 토끼 유래 IgG 항체입니다. Western blot과 IHC(P) 적용 가능하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZP2 (Accession Q05996), corresponding to amino acid residues G681–G731 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900784 |
Product Specific Information
This antibody detects endogenous levels of total ZP2.
Target Information
The zona pellucida is an extracellular matrix surrounding the oocyte and early embryo. It consists primarily of three or four glycoproteins with roles in fertilization and preimplantation development. The protein encoded by the ZP2 gene is a structural component of the zona pellucida, functioning in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein includes:
- N-terminal signal peptide sequence
- Conserved ZP domain
- Consensus furin cleavage site
- C-terminal transmembrane domain
Furin cleavage is hypothesized to release the mature protein for incorporation into the zona pellucida matrix, though its necessity remains controversial based on mouse studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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