Thermo Fisher Scientific Human STK4 (MST1), GST Tag Recombinant Protein

Thermo Fisher Scientific Human STK4 (MST1), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of the 5 µg, 10 µg, and 20 µg sizes are not recommended; use in original packaging until exhausted.
• For larger sizes, reduce freeze/thaw cycles by preparing aliquots (below 20 µL not recommended).
• Never store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.
• Protein Form: Recombinant, Full Length

Target Information

STK4 (MST1) is a serine/threonine kinase involved in apoptosis and chromatin condensation. It is a stress-activated, pro-apoptotic kinase that, upon caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.
STK4 is a key component of the Hippo signaling pathway, crucial for organ size control and tumor suppression by limiting proliferation and promoting apoptosis.
In this pathway, STK3/MST2 and STK4/MST1, with SAV1, activate LATS1/2 and MOB1, which phosphorylate and inactivate YAP1 and WWTR1/TAZ. Phosphorylation of YAP1 prevents its nuclear translocation, regulating genes related to proliferation, cell death, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.