Thermo Fisher Scientific L3MBTL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 746-829. Recombinant protein control fragment (Product #RP-108536). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:L3MBTL1,uniProtId:Q9Y468-5,ncbiNodeId:9606,antigenRange:746-829,antigenLength:840,antigenImageFileName:PA5-144881_L3MBTL1_Q9Y468-5_Rabbit.svg,antigenImageFileNamePDP:PA5-144881_L3MBTL1_Q9Y468-5_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092133

Product Specific Information

Immunogen sequence: STVAKWTIDE VFGFVQTLTG CEDQARLFKD EARIVRVTHV SGKTLVWTVA QLGDLVCSDH LQEGKGILET GVHSLLCSLP THLL

Antigen sequence identity: Mouse 33%; Rat 31%

Target Information

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.