Thermo Fisher Scientific CYP46A1 Polyclonal Antibody
CYP46A1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 IHC에 적합합니다. Human 및 Mouse 시료에서 반응하며, 고순도의 affinity chromatography로 정제되었습니다. 뇌 내 콜레스테롤 대사 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CYP46A1 (amino acids 223–250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 30% glycerol |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691855 |
Product Specific Information
Predicted to react with Mouse samples.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. These proteins are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
CYP46A1 is an endoplasmic reticulum protein expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot cross the blood-brain barrier, 24S-hydroxycholesterol can be secreted into circulation and transported to the liver for catabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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