Thermo Fisher Scientific GPR20 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA3-068 detects GPR20 from mouse samples.
It has been successfully used in Western blot, immunocytochemistry, and immunohistochemistry procedures.
By Western blot, this antibody detects a 39 kDa protein corresponding to mouse GPR20.
The PA3-068 antigen is the COOH-terminal amino acids of mouse GPR20 (338–358) IHILSIGSHTLTQPLTNGPEP coupled to KLH.

Target Information

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors or 7TM receptors, comprise a superfamily of proteins involved in various stimulus-response pathways.
GPR signaling is an ancient mechanism used by eukaryotes to sense environmental stimuli and mediate cell-cell communication.
These receptors translate extracellular signals into intracellular signals via G protein activation and respond to hormones and neurotransmitters.
GPR20 is a 358 amino acid membrane protein that constitutively activates G(i) proteins without ligand stimulation.
It may regulate intracellular cAMP levels and mitogenic signaling.
GPR20 is expressed in liver and certain brain regions (putamen, caudate, thalamus), but not in hypothalamus, pons, or frontal cortex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.